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1.
ImplantNewsPerio ; 2(1): 126-136, jan.-fev. 2017. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-847094

ABSTRACT

Objetivo: avaliar in vitro a efetividade de aplicações sucessivas de diferentes produtos utilizados para o tratamento da hipersensibilidade dentinária cervical na redução da permeabilidade dentinária, assim como avaliar a resistência destes produtos a desafios ácidos. Material e métodos: foram utilizados 72 terceiros molares humanos íntegros para a preparação de 72 amostras, que foram ligadas a um sistema de pressão hidráulica para mensurar a permeabilidade dentinária após os seguintes passos: 1) preparação da amostra; 2) tratamento com ácido fosfórico a 37% durante 30 segundos; 3) cinco aplicações dos produtos testados; 4) primeiro desafio ácido; 5) segundo desafio ácido; e 6) terceiro desafio ácido. As amostras foram divididas aleatoriamente em seis grupos (n=12), de acordo com os tratamentos propostos: Desensibilize Nano P, Clinpro XT, dentifrício Colgate Sensitive Pró-Alívio, dentifrício Duraphat, dentifrício Sensodyne Repair e após restauração com resina composta (grupo-controle). Conclusão: que todos os produtos testados foram capazes de promover a redução da permeabilidade dentinária significativamente, sendo que os grupos Clinpro XT, Desensibilize Nano P e controle mantiveram esses níveis reduzidos estatisticamente até o terceiro desafio ácido, enquanto que os dentifrícios Duraphat, Sensodyne Repair e Colgate Sensitive Pró-Alívio mantiveram essas reduções estatisticamente significativas até o segundo desafio ácido.


Objective: to evaluate in vitro the effectiveness of successive applications of different products used for the treatment of cervical dentinal hypersensitivity, reducing dentin permeability, as well as to evaluate the resistance of these products, acids challenges. Material and methods: 72 intact human third molars were used for the preparation of 72 samples were bound to a hydraulic pressure system to measure the dentin after the following steps: 1) sample preparation; 2) treatment with 37% phosphoric acid for 30 seconds; 3) 5 applications of the products tested; 4) first challenge acid; 5) second challenge acid; 6) third challenge acid. The samples were randomly divided into 6 groups (n=12) according to the proposed treatments: Desensibilize Nano P, Clinpro XT, toothpaste Colgate Sensitive Pro-Relief, Duraphat toothpaste, toothpaste Sensodyne Repair and after restoration with composite resin (control group). Conclusion: all products tested were able to significantly promote the reduction of dentin, and the Clinpro XT groups Desensibilize Nano P and control these reduced levels remained statistically to the third challenge acid, while toothpaste Duraphat, Sensodyne Repair and Colgate Sensitive Pro-Relief kept these statistically significant reductions to the second challenge acid.


Subject(s)
Humans , Dentin , Dentin Permeability/drug effects , Dentin Sensitivity/drug therapy , Pharmaceutical Preparations, Dental/administration & dosage
2.
EMHJ-Eastern Mediterranean Health Journal. 2016; 22 (6): 404-410
in English | IMEMR | ID: emr-181494

ABSTRACT

No study has investigated the availability and adherence of preventive oral care products on the Syrian market to evidence-based international recommendations. Data were collected in 2012, and updated in 2016, in terms of availability, characteristics and adherence to evidence-based international recommendations. Few preventive products adhered to the recommendations. Despite the large decrease in the number of oral care products on the Syrian market, due to the Syrian crisis, nonadherence of some of the available products is still present. A multisectorial approach at a policy level is needed to address such important limitations. The Syrian Ministry of Health should reform regulations for fluoride products to become subject to drug monitoring systems; the Syrian Arab Committee for Measurements and Standards needs to update its standards; and the Syrian General Dental Association should distribute a preventive booklet to dental practitioners


Subject(s)
Humans , Pharmaceutical Preparations, Dental/chemistry , Medication Adherence , Dental Care/methods , Oral Hygiene , Evidence-Based Dentistry/methods
3.
EMHJ-Eastern Mediterranean Health Journal. 2016; 22 (8): 579-585
in English | IMEMR | ID: emr-183455

ABSTRACT

The aim of this study was to describe the oral health, general health status and medication use of elderly dental patients 709 voluntary patients, aged 60 years and over, who attended Suleyman Demirel University Faculty of Dentistry for routine dental treatment between March 2008 and April 2009 in Isparta, Turkey, were interviewed for demographic data, systemic diseases, and lists of medications. The majority of the patients [84.4%] had poor oral hygiene according to the Oral Hygiene Index [OHI]. The mean level of the study population's decayed, missing, and filled teeth [DMFT] index score was 19.1 +/- 7.3. The prevalence of systemic diseases was high [90%]. Women were affected by a significantly higher incidence of systemic diseases than men [96.4% vs. 84.3%; P < 0.001]. The percentage of the elderly taking medication regularly was 72.6%. Drug adverse effects were determined in 25.5% of the study population, with more adverse effects observed in women [53.3%] than men [46.7%] [P < 0.001]. Dentists must be aware of the dental implications that may arise from systemic diseases and medications and should properly modify elderly patients' treatment accordingly


Subject(s)
Humans , Female , Male , Middle Aged , Aged , Aged, 80 and over , Dental Health Surveys/methods , Health Services for the Aged , Dental Research , Pharmaceutical Preparations, Dental/adverse effects , Oral Hygiene/standards , Surveys and Questionnaires
4.
Article in English | IMSEAR | ID: sea-159457

ABSTRACT

The environment of oral cavity provides a large surface area for the delivery of drugs bypassing the first pass metabolism in the liver. Hence, the oral cavity is being targeted for providing quicker delivery of drugs for immediate action. However, oral delivery system in the form of tablets/ capsules needs modifications in elderly, children, and unconscious patients because of the fear of choking and aspiration. To overcome these problems much research is being undertaken to develop oral bio dissolving films as an alternative to tablets. The objective of the article was to provide an overview of the composition, advantages and disadvantages, and uses of bio dissolving films in the field of medicine and dentistry.


Subject(s)
Administration, Oral , Airway Obstruction/prevention & control , Biofilms/classification , Coated Materials, Biocompatible , Dentistry/drug therapy , Dentistry/therapy , Drug Delivery Systems , Humans , Pharmaceutical Preparations, Dental/administration & dosage , Polyvinyls
5.
Belo Horizonte; s.n; 2015. 96 p. ilus, tab.
Thesis in Portuguese | LILACS, BBO | ID: lil-790320

ABSTRACT

Cirurgiões-dentistas têm a prerrogativa de prescrever medicamentos como adjuvantes ao tratamento odontológico. Em 2011, com a promulgação da Resolução de Diretoria Colegiada no 20 da Agência Nacional de Vigilância Sanitária - ANVISA, antibióticos se tornaram medicamentos sujeitos a prescrição especial. Este estudo transversal descritivo buscou conhecer o ato prescricional dos cirurgiões-dentistas quanto aos antibióticos, identificar os mais prescritos, determinar se houve erro no atendimento das determinações legais e identificar erros na prescrição profilática. Foram analisadas prescrições odontológicas de antibióticos aviadas na maior rede de drogarias de Belo Horizonte, Minas Gerais, de 1º de julho de 2011 a 30 de junho de 2012. No período da coleta de dados havia 75 lojas em funcionamento. Foi possível recuperar informações sobre as prescrições de 69 delas (Taxa de retorno=92,0%). Para o universo, 31.105 prescrições, foi realizado um sorteio da amostra, com cálculo baseado na estimativa de proporções (50% de proporção estimada de prescrição com erro, 5% de precisão e nível de confiança de 95%). Foram sorteadas 434 prescrições, pela técnica de amostragem aleatória simples. Após exclusão daquelas com repetição de prescritor e/ou de paciente, foram analisadas 366 prescrições. A precisão recalculada para este montante foi igual a 5,09%. Após dupla digitação no programa Epi-Data foi criado um banco de dados no programa SPSS. A pesquisa foi submetida e aprovada pelo Comitê de Ética em Pesquisa da UFMG. Os resultados das análises demonstraram que a maioria dos antibióticos prescritos pertence ao grupo das penicilinas (71,9%) e dos macrolídeos (17,6%). Também foram prescritos, em menor proporção, antibióticos para aplicação cutânea e vários outros, incluindo antifúngicos, além de associações: amoxicilina com ciprofloxacino e com clindamicina...


Dentists have the prerogative to prescribe drugs as adjuncts to dental treatment (BRASIL, 1966). In 2011, with the enactment of the Collegiate Board Resolution no.20 of the National Health Surveillance Agency - ANVISA, antibiotics became drugs subject to special prescription. This descriptive cross-sectional study aimed to know the limitation act of dentists as to antibiotics, identify the most prescribed, determine if there was an error in meeting the legal requirements and identify errors in prophylactic prescription. Dental antibiotic prescriptions filled in the largest drugstore chain in Belo Horizonte, Minas Gerais were analyzed from 1 July 2011 to 30 June 2012. In the period of data collection there were 75 stores in operation. It was possible to retrieve information about the prescriptions of 69 of them (return rate = 92%). For the study of 31,105 prescriptions, there was a draw of the sample, with calculation based on estimated proportions (50% of estimated proportion with prescription error, 5% precision and 95% of confidence level). 434 prescriptions were selected by the simple random sampling technique. After excluding those with repeating prescriber and / or patient, 366 prescriptions were analyzed. The accuracy recalculated for this amount was equal to 5.09%. After double entry in Epi-Date program it was created a database in the SPSS software. The research was subjected and approved by the Ethics Committee of UFMG. The results of analysis showed that most prescribed antibiotics belong to the group of penicillins (71.9%) and macrolides (17.6%). Also were prescribed, to a lesser extent, antibiotics for topical application and several others, including antifungal, in addition to associations: amoxicillin with ciprofloxacin and clindamycin. In 27.9% of the prescriptions there were errors in spelling or disobedience to the determination to follow the Brazilian Common Denomination (DCB)...


Subject(s)
Anti-Bacterial Agents/therapeutic use , Drug Prescriptions , Inappropriate Prescribing , Macrolides/therapeutic use , Penicillins/therapeutic use , Pharmaceutical Preparations, Dental/therapeutic use , Brazilian Health Surveillance Agency , Cross-Sectional Studies
6.
Article in English | IMSEAR | ID: sea-159318

ABSTRACT

The orthodontic tooth movement is a biological response to orthodontic force. The biological response is very strongly-related to local bone metabolism. There is a strong evidence in the literature that bone metabolism can be altered by drugs. There are various studies published in dental journals on administration of drugs for the purpose of affecting orthodontic tooth movement both for augmentation of anchorage and to increase the rate of tooth movement. Most of these studies are animal studies. The aim of this article is to give insight to how to convert drug dose from animal studies to human trails. Dose per kilogram of body weight for one species is not the same for another species, it has to be converted first based on body surface area (BSA)normalization method. BSA correlates well across several mammalian species with several parameters of biology, including oxygen utilization, caloric expenditure, basal metabolism, blood volume, circulating plasma proteins, and renal function.


Subject(s)
Animals , Animal Experimentation , Body Surface Area/veterinary , Dose-Response Relationship, Drug , Drug Administration Schedule , Humans , Models, Animal/drug effects , Models, Animal/drug therapy , Pharmaceutical Preparations, Dental/administration & dosage , Plethysmography/drug effects , Plethysmography/methods , Reference Standards , Tooth Movement Techniques/methods , Tooth Movement Techniques/pharmacology
7.
Braz. dent. sci ; 17(3): 3-10, 2014. tab
Article in English | LILACS, BBO | ID: lil-743027

ABSTRACT

Dental treatment of pregnant women should be accomplished with safety. Consequently, the dental professional should evaluate its real need and risks for the mother and child. This paper reports through a literature review, the caution with the clinical dental procedures commonly performed and possible risks of the therapeutic agents used, allowing the dentist to evaluate the treatment and the drug to be administered to the pregnant women


O tratamento odontológico da gestante deve ser realizado com segurança, e para isto deve-se avaliar a real necessidade de sua execução e os riscos que o mesmo poderá trazer para a mãe e para o bebê. Este artigo relata, com base em uma revisão de literatura, os cuidados com os procedimentos clínicos comumente realizados no consultório odontológico e os possíveis riscos dos agentes terapêuticos utilizados, permitindo ao clínico avaliar o tratamento e a droga a serem administrados às gestantes.


Subject(s)
Humans , Female , Pregnancy , Dental Offices/methods , Pharmaceutical Preparations, Dental , Pregnant Women , Therapeutics
8.
Rev. Asoc. Odontol. Argent ; 101(4): 123-124, dic. 2013.
Article in Spanish | LILACS | ID: lil-702198

ABSTRACT

Compete a la Adminsitración Nacional de Medicamentos, Alimentos y Tecnología Médica (AMMAT) garantizar que los medicamentos, alimentos y dispositivos médicos a disposición de la población posean eficacia, seguridad y calidad. Dentro de su estructur, la Dirección Nacional de Productos Médicos es la encargada de controlar, fiscalizar; evaluar y vigilar los de uso odontológico. Simultáneamente, es responsabilidad del odontólogo verificar que los productos que utiliza estén aprobados por la ANMAT e informar, dentro del sistema denominado de odontovigilancia, las dificultades y efectos no deseados derivados de su utilización. De particular importancia, dentro de las disposiciones de la ANMAT, es la relacionada con las condiciones en las que deben llevarse a cabo los ensayos clínicos de productos médicos. Su contenido relacionado con las responsabilidades, la elaboración de protocolos de investigación y otros aspectos deben tenerse en cuenta en el momento de solicitar la conformidad para encarar la evaluación de productos en su fase de desarrollo.


Subject(s)
Drug Evaluation , Legislation, Drug , Regulations for Policy Organizations , Argentina , Drug Evaluation/legislation & jurisprudence , Legislation, Drug/organization & administration , Pharmaceutical Preparations, Dental/analysis
9.
Ortodontia ; 45(3): 248-256, maio-jun. 2012. tab, graf
Article in Portuguese | LILACS, BBO | ID: lil-714094

ABSTRACT

Objetivos: o objetivo deste trabalho foi avaliar a eficiência do uso de anestésico tópico para inserção de mini-implantes utilizados como meio de ancoragem esquelética em Ortodontia. Material e Métodos:o anestésico tópico a base de lidocaína 20% em gel foi utilizado para inserção de mini-implantes em 40 pacientes em tratamento com aparelhos fixos. A idade média dos pacientes era 23,58 anos. Os pacientes responderam a um questionário com quatro perguntas de múltipla escolha, avaliando a aceitabilidade e o desconforto durante a anestesia e a colocação do mini-implante. Os dados foram avaliados em porcentagem e pelo teste qui-quadrado para avaliação do dimorfismo sexual. Resultados: 92,5% dos pacientes relataram que não sentiram nenhum incômodo durante a aplicação do anestésico tópico e apenas7,5% sentiram uma leve dormência, o que mostra que o anestésico teve boa aceitação pelos pacientes. Em relação ao procedimento de instalação dos mini-implantes, somente 20% dos indivíduos da amostra relacionaram a dor (independente da intensidade) como a sensação mais desagradável durante todo o procedimento de colocação do mini-implante.Entretanto, 47,5% dos pacientes não sentiram dor alguma e apenas10% dos pacientes sentiram dor intensa. Houve diferença entre os gêneros apenas com relação à sensação mais desagradável durante todo o procedimento, sendo que a maioria das mulheres (55%) relatou não ter sentido nada desagradável, comparando com apenas 40% dos homens. Conclusão: a instalação de mini-implantes com anestésico tópico se mostrou viável e eficiente, podendo ser uma alternativa, mas são necessários mais estudos e comparações com outros métodos de anestesia.


Objectives: the objective of this study was to evaluate the efficiency of the use of topical anesthetics for insertion of miniimplants used as skeletal anchorage in orthodontics. Material and methods: the topical anesthetics based in lidocaine gel 20% was used to the insertion of mini-implants in 40 patients in treatment with fixed appliances. The mean age of the patients was 23.58 years. Patients answered to a questionnaire with 4 multiple choice questions, evaluating the acceptability and discomfort of the patients during anesthetics and placement of mini-implant. Data were evaluated by percentage and by the chi-square test to evaluate the sexual dimorphism. Results:92.5% of the patients reported that did not feel any discomfort during the application of the topical anesthetics, and only 7.5% felta slight dormancy, what shows that the anesthetics presented good acceptance by the patients. In relation to the procedure of installation of mini-implants, only 20% of the subjects related pain (regardless ofthe intensity) as the more unpleasant sensation during the procedure of placement of the mini-implant. However, 47.5% of the patients did not feel any pain and only 10% of the subjects felt intense pain. There was difference between sexes only regarding the more unpleasant sensation during the procedure, and the majority of the females (55%)reported not to feel any unpleasant sensation, comparing with only 40% of the males. Conclusion: the installation of mini-implants with topical anesthetics proved to be feasible and effective, it could bean altemative, but more studies and comparisons with other type of anesthesia are necessary.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Anesthetics/administration & dosage , Anesthetics/adverse effects , Anesthetics/therapeutic use , Dental Implants , Orthodontics , Pharmaceutical Preparations, Dental , Chi-Square Distribution , Data Interpretation, Statistical , Lidocaine , Orthodontic Appliances , Surveys and Questionnaires
10.
Ortodontia ; 45(2): 202-208, mar.-abr. 2012. ilus
Article in Portuguese | LILACS, BBO | ID: lil-713968

ABSTRACT

Nos computadores pessoais, o overclock é um processono qual uma maior velocidade de processamento é conseguida atravésde configurações e instruções diretas para o hardware, superando oslimites de desempenho originais. As técnicas que visam aumentar avelocidade do movimento dentário induzido e, consequentemente, otratamento ortodôntico são aqui chamadas de overclock ortodôntico. Aduração prolongada do tratamento ortodôntico foi considerada o fatormais desconfortável do tratamento por 45% por pacientes, em estudosrealizados no Brasil e na Ásia. Esse também é um dos principaisfatores que desmotivaram o paciente adulto a iniciar o tratamentoortodôntico". O tempo aumentado de tratamento pode ser atribuídoà forma de geração da força ortodôntica (fios ortodônticos); ao meiode transferência das forças ao ligamento periodontal (braquetes eacessórios); ou ainda à insuficiente mobilização biológica para osfenômenos de reabsorção, essenciais à movimentação ortodôntica.Este trabalho buscou discutir as técnicas de intervenção na biologiae na mecânica do movimento ortodôntico com o objetivo de reduzir otempo total do tratamento. Pôde-se concluir que as intervenções feitaspara reduzir a intensidade da força necessária para o movimento e oaumento dos níveis de mediadores inflamatórios estão associadas aoaumento da taxa de movimento. A inflamação, no entanto, tem vantagense desvantagens, pois enquanto pode ser benéfica para acelerar amovimentação e a remodelação óssea, pode ser causadora de perdasperiodontais e da estrutura dentária.


On personal computers, overclocking is a processwhereby a higher processing speed is achieved through directinstructions and settings for hardware, surpassing the originalperformance limits. The techniques that aim to increase the speed oftooth movement and consequently the orthodontic treatment are hereinreferred to as orthodontic overclocking. The prolonged duration oforthodontic treatment was considered the single most uncomfortabletreatment for 45% of patients in studies conducted in Brazil and Asia1'2. This was also one of the main factors that discourage the adultpatient starting orthodontic treetment". The increased of treatmenttime can be attributed to the form of generation of orthodontic force(orthodontic wiresJ through the transfer of forces to the periodontalligament (brackets and accessoriesJ ar the insufficient mobilization forthe biological phenomena of resorption, essential to the orthodonticmovement. This paper discusses intervention techniques in biologyand mechanics of orthodontic movement, aiming to reduce the totaltreatment time. It can be concluded that interventions designed toreduce the amount of force required for movement and increasedlevels of inflammatory mediators are associated with increased rate ofmovement. Inflammation, however, has advantages and disadvantages,as it may be beneficial to accelerate the movement and bane turno ver,can cause loss of periodontal and tooth structure.


Subject(s)
Humans , Computational Biology , Inflammation , Tooth Movement Techniques/trends , Pharmaceutical Preparations, Dental
11.
Belo Horizonte; s.n; 2012. 57 p. ilus, tab.
Thesis in Portuguese | LILACS, BBO | ID: lil-790312

ABSTRACT

Pacientes submetidos a tratamento com aparelhos fixos estão sujeitos a apresentar alterações periodontais significativas. Os acessórios ortodônticos adaptados às coroas dentárias dificultam a manutenção da higiene bucal ao criando um aumento significativo de superfícies retentivas, favorecendo o acúmulo do biofilme bacteriano. Caracterizando um desequilíbrio na microflora local contribuindo para o desenvolvimento de alterações periodontais. O objetivo deste estudo foi comparar a efetividade de um novo sistema de liberação controlada de clorexidina na formulação 0,6% e tratamento profilático no controle da placa e gengivite em pacientes ortodônticos. Este estudo foi constituído de 29 indivíduos provenientes de clínicas do Curso de Especialização em Ortodontia da Faculdade de Odontologia da Universidade Federal de Minas Gerais com diagnóstico de gengivite...


Subject(s)
Humans , Male , Female , Adolescent , Orthodontic Appliances , Chlorhexidine/therapeutic use , Gingivitis , Oral Hygiene , Dental Plaque/prevention & control , Dental Prophylaxis , Periodontal Diseases , Pharmaceutical Preparations, Dental/administration & dosage
12.
Ortodontia ; 44(6): 573-578, nov.-dez. 2011.
Article in Portuguese | LILACS, BBO | ID: lil-713845

ABSTRACT

A Ortodontia está fundamentada na habilidade do profissional em produzir umacontrolada movimentação dos dentes através do osso alveolar, a partir da aplicação da forçaortodôntica. Entretanto, a movimentação ortodôntica pode ser influenciada por vários fatores,dentre eles, o uso de medicamentos. Em vista do exposto, o objetivo deste trabalho foirealizar uma revisão narrativa da literatura sobre a influência de fármacos ou suplementos namovimentação dentária induzida. Como a maior parte dos trabalhos foi realizada com animaise não com humanos e há grande variabilidade entre as metodologias, não se pode afirmarcategoricamente sobre qualquer modificação na movimentação ortodôntica causada poralgum tipo de fármaco que o paciente utilize durante o tratamento ortodôntico. Vislumbra-se,futuramente, atuar na taxa da movimentação ortodôntica com o auxílio de medicamentos.


Orthodontics is based on the professional's ability to produce a controlledteeth movement in alveolar bone through the application of orthodontic force. However, theorthodontic movement may be influenced by several factors, including the use of medicines.Due to it, the aim of this study was to perform a narra tive literature review on the effectsof drugs on experimental tooth movement. As most experimental studies were done withanimais instead of humans and there is a great variability among the methodologies, stetementscannot yet be done about any change in tooth movement caused by some kind ofmedication took by patients during orthodontic treatment. We envision in the future actingon orthodontic tooth movement with the aid of drugs.


Subject(s)
Drug Utilization , Tooth Movement Techniques , Pharmaceutical Preparations, Dental/administration & dosage , Pharmaceutical Preparations, Dental/adverse effects , Adrenal Cortex Hormones , Anti-Inflammatory Agents, Non-Steroidal , Diphosphonates , Osteocalcin , Prostaglandins
13.
Arch. venez. farmacol. ter ; 30(3): 61-63, jul.-sept. 2011. graf
Article in Spanish | LILACS | ID: lil-706171

ABSTRACT

La Farmacovigilancia tiene como objeto proporcionar información sobre la seguridad de los medicamentos que se encuentran en el mercado con el fin de asegurar que la relación riesgo/beneficio sea favorable. El propósito de este trabajo fue analizar los reportes de Farmacovigilancia recibidos y así permitir cuantificar las RAM. Se realizó un estudio retrospectivo de las notificaciones recibidas en el periodo agosto de 2008 hasta agosto de 2009. Se recibieron 100 reportes observando un aumento en el tiempo, refiriéndo se la mayoría a efectos adversos, siendo menor la falta de eficacia. El rango de edades reportadas fue de 19-80 años. El fármaco más reportado fue Enalapril, la mayoría de los reportes hace referencia a la vía oral y que tras el inconveniente con la medicación se debió realizar tratamiento. La mitad de las planillas vienen incompletas. La mayoría de las reacciones adversas a medicamentos fueron leves y se resolvieron sin secuelas. Para las comunicaciones se utilizó la Ficha de Farmacovigilancia, la cual se puso a disposición de los Profesionales y alumnos de los últimos años de la carrera de Odontología.


Pharmacovigilance is intended to provide information on the safety of the drugs found in the market in order to ensure that the risk/benefit ratio is positive. The purpose of this paper was analyzing pharmacovigilance reports received and thus allow the RAM to quantify. A retrospective study of the notifications received during the period was conducted August 2008 until August provide received 100 reports noting an increase in the time, referring the most adverse effects, the lack of effectiveness being lower. The reported ages range was 19-80 years. The most reported drug was Enalapril, the majority of the reports refers to the mouth and that after the problem with the medication should carry out treatment. Half of the forms are incomplete. The majority of adverse drug reactions were mild and resolved without sequelae. Pharmacovigilance data, which was put at the disposal of professionals and students in the last years of the career of dentistry was used for communications.


Subject(s)
Humans , Pharmacovigilance , Pharmaceutical Preparations, Dental/radiation effects , Pharmaceutical Preparations/radiation effects , Risk Assessment , Pharmacology
14.
Indian J Med Sci ; 2011 Feb; 65(2) 73-82
Article in English | IMSEAR | ID: sea-145594

ABSTRACT

Drugs used locally or systemically induce several alterations in micro and macroscopic tissues. However, nearly 20 drugs have been reported so far in the literature associated with gingival enlargement. Many systemic diseases have limited therapeutic options and such drugs or their metabolites have an adverse influence on different systems/organs, and one of these is that they initiate or accelerate the overgrowth of gingival tissue. The increase in size may be to the extent that teeth may be partially or completely covered, and the resultant 'gummy smile' may result in aesthetic concern for the patient.In the presence of bacterial inflammation in the gingiva, many of these drugs enhance the production of collagen by fibroblast cells, and simultaneously retard the destruction of collagen and hence increase the bulk of gingival tissue. It is apparent that there is a subpopulation of fibroblasts which is sensitive to these drugs. The exuberant growth of gingival tissue is of great aesthetic concern, which may require mechanical removal of bacterial plaque, calculus, and surgical intervention, and/or substitution of the drug with analogs. A relatively healthy oral environment provided by the dentist will reduce local microflora that will help in eliminating the major focus of infection. Physicians, general practitioners, and dentists need to make a coordinated and concise treatment plan that will be beneficial for the patients. This article will facilitate full information to physicians to involve dentists in the multidisciplinary treatment plan.


Subject(s)
Collagen/physiology , Combined Modality Therapy , Cyclosporine , Dental Deposits/therapy , Dental Plaque/therapy , Fibroblasts/drug effects , Gingival Overgrowth/epidemiology , Gingival Overgrowth/etiology , Gingival Overgrowth/drug therapy , Gingival Overgrowth/surgery , Gingival Overgrowth/therapy , Gingivitis/epidemiology , Gingivitis/etiology , Gingivitis/drug therapy , Gingivitis/surgery , Gingivitis/therapy , Humans , Pharmaceutical Preparations, Dental/therapeutic use , Phenytoin/therapeutic use , Review Literature as Topic
15.
Dent. press endod ; 1(1): 77-81, 2011. tab
Article in Portuguese | LILACS, BBO | ID: lil-685767

ABSTRACT

Introdução: existe a possibilidade da medicação intracanal à base de hidróxido de cálcio persistir no interior dos canais radiculares mesmo após a tentativa de remoção no momento da obturação. Objetivos: avaliar, por microscopia eletrônica de varredura, a persistência de resíduos no interior do canal radicular oriundos de medicações intracanal à base de Ca(OH)2 associado a diferentes veículos.Métodos: 36 incisivos bovinos tiveram suas coroas seccionadas,os canais radiculares preparados e separados aleatoriamente em seis grupos distintos, de acordo com o tipo de pasta medicamentosa a ser utilizada. No Grupo I(controle), os canais não receberam qualquer tipo de medicação intracanal. No Grupo II, os canais foram totalmente preenchidos com pó de hidróxido de cálcio P.A. O Grupo III recebeu uma mistura de Ca(OH)2 com soro fisiológico,enquanto os canais do Grupo IV foram preenchidos com Ca(OH)2 misturado com glicerina. Hidróxido de cálcio associado a propilenoglicol 400 ou polietilenoglicol 400 foi utilizado nos Grupos V e VI, respectivamente. Após uma semana, a medicação intracanal foi removida, as raízes cisalhadas e preparadas para observação em microscópio eletrônico de varredura. Fotomicrografias representativas do terço apical de cada grupo experimental foram obtidas e analisadas quantitativamente por meio de grade de integração,com resultados expressos em porcentagem de debris recobrindo as paredes dentinárias. Resultados: a análise estatística (análise de variância complementada por teste de Tukey, α=0,05) evidenciou diferenças significativas entre os grupos testados, indicando que o hidróxido de cálcio associado ao propilenoglicol ou polietilenoglicol apresentou maior persistência de resíduos no canal. As paredes dentinárias de canais que receberam medicação à base de hidróxido de cálcio puro ou associado à glicerina apresentaram quantidades de debris semelhantes ao grupo controle. Conclusões: medicamentos à base de Ca(OH)2 puro ou sua associação com...


Introduction: There is a possibility of intracanal medicationremain in the root canal even after its removal priorto obturation. The present study aims to evaluate underscanning electron microscopy the persistence of residuesin the root canal from calcium hydroxide medicationsprepared with different vehicles. Methods: Thirtysixbovine incisors had their crowns removed, the rootcanals prepared and were assigned randomly to six differentexperimental groups, according to the intracanalmedication used. Group I (control) received no intracanalmedication, whereas root canals of Group II were filledwith P.A. calcium hydroxide. Group III received a mixtureof Ca(OH)2 and saline solution, in Group IV glycerin wasused as vehicle, and Groups V and VI received Ca(OH)2mixed with propylene glycol or polyethylene glycol 400,respectively. After one week, medication was removed,roots were split and the canals observed under the scanningelectron microscope. Representative photomicrographsof the apical third of each experimental groupwere observed and analyzed quantitatively by means ofa grid, with results expressed in percentage of canal wallscovered by debris. Results: Statistical analysis (one-wayANOVA and Tukey’s post hoc test, α=0.05) revealedsignificant differences between groups, indicating higheramounts of Ca(OH)2 residues in the canals where propyleneglycol or polyethylene glycol were used as vehicles.The dentinal walls of the canals that received pure P.A.calcium hydroxide or its association to glycerin presentedamounts of debris similar to the control group. Conclusions:Ca(OH)2 P.A. based medications or its associationto glycerin allows an easier removal from the root canal.


Subject(s)
Animals , Cattle , Calcium Hydroxide , Root Canal Irrigants , Microscopy, Electron, Scanning , Pharmaceutical Preparations, Dental , Root Canal Therapy
16.
RFO UPF ; 15(1): 35-39, jan.-abr. 2010. ilus, tab
Article in Portuguese | LILACS, BBO | ID: biblio-874052

ABSTRACT

Este estudo teve como objetivo avaliar, por meio do método de difusão em BHI ágar, a ação antimicrobiana de quatro formulações a base de hidróxido de cálcio utilizadas como medicação intracanal. Para tanto foram utilizadas tres cepas microbianas: Enterococcus faecalis, Bacillus subtilis e Candida albicans. Com base na análise dos resultados, por meio do teste eststístico Kruskal-Wallis complementado pelo teste de comparações múltiplas ao nível de significância de 5 por cento, foi constatado que o Calen com ou sem PMCC e o Hydrocal sem iodofórmio apresentaram ação antimicrobiana contra as tres culturas empregadas sem haver diferença eststística significativa. Hydrocal com iodoformio não teve ação contra as culturas de Candida albicans e Enterococcus faecalis, somente contra Bacillus subtilis


Subject(s)
Endodontics , Calcium Hydroxide , Pharmaceutical Preparations, Dental , Drug Resistance , Root Canal Therapy
17.
Belo Horizonte; s.n; 2010. 36 p. ilus.
Thesis in Portuguese | LILACS, BBO | ID: lil-715943

ABSTRACT

Considerando a importância da avaliação de sistemas para o atendimento odontológico, avaliou-se a prevalência de alteações sistêmicas e da utilização de medicamentos entre usuários das clínicas odontológicas de um curso de Odontologia em Belo Horizonte, Minas Gerais e os fatores associados à utilização de fármacos, 2004...


Subject(s)
Humans , Male , Female , Pharmacology/standards , Drug Interactions/ethnology , Pharmaceutical Preparations, Dental/therapeutic use , Systemic Management/methods , Dental Records/classification
18.
San Salvador; s.n; 2005. 122 p. Tab, Graf.
Thesis in Spanish | LILACS, BISSAL | ID: biblio-1248309

ABSTRACT

La presente investigación, se realizó con estudiantes de VII, IX ciclo y docentes, programados en las diferentes áreas de las clínicas intramurales de la Facultad de Odontología de la Universidad de El Salvador en el periodo de noviembre a diciembre del 2003, pasándose una cédula de entrevista a 30 docentes, 31 estudiantes de IX Ciclo y 41 de VII Ciclo. Está investigación se llevó a cabo con el propósito de aportar conocimientos actualizados sobre fármacos y en el caso especifico del área aplicada en odontología, donde se plasma la necesidad de contar con un cuadro básico odontológico, ya que nuestra facultad no cuenta con ello; además de tener escasa bibliografía. En este documento se da ha conocer la importancia de prescribir un medicamento adecuadamente, evitando así muchos problemas en la terapéutica. A lo largo de la historia se denota la importancia de la constante investigación en el área de farmacología dando como resultado en la actualidad un libro de consulta generalizada para el área médica (PLM); en el caso de la farmacología aplicada en odontología se podría decir que es una rama que esta surgiendo con escasa información al respecto, por lo que se hace necesario que se evalúe teóricamente y científicamente una recopilación de sustancias químicas utilizadas en el campo de la odontología. Esta investigación demostró la necesidad de tener a la mano un cuadro básico de medicamentos siendo este una guía específica para la institución y áreas de odontología, Ya que los resultados encontrados fueron: En el grupo de los analgésicos 87 prescriben acetaminofén, en sedantes 34 prescriben diazepan, relajantes musculares 56 prescriben metocarbamol, en antibióticos 63 prescriben amoxicilina, en antivirales 37 prescriben aciclovir, en el grupo de antimicóticos y antibacterianos el ketoconazol y metronidazol, ambos son prescritos por 14 sujetos respectivamente. En las vitaminas 34 prescriben vitamina C y 49 flúor, en otros medicamentos 42 indican dentífrico con cloruro de sodio y triclósan. 18 indican desensibilizantes con clorhidrato de bencidamina y 44 indican clorhexidina como enjuague bucal.


This research was carried out with students of the VII, IX cycle and teachers, programmed in the different areas of the intramural clinics of the Faculty of Dentistry of the University of El Salvador in the period from November to December 2003, passing a certificate of interviews 30 teachers, 31 students of the IX Cycle and 41 of the VII Cycle. This research was carried out with the purpose of providing updated knowledge on drugs and in the specific case of the applied area in dentistry, where the need for a basic dental picture is reflected, since our faculty does not have it; besides having little bibliography. In this document, the importance of prescribing a drug properly is disclosed, thus avoiding many problems in therapeutics. Throughout history, the importance of constant research in the area of ​​pharmacology has been denoted, currently resulting in a generalized reference book for the medical area (PLM); In the case of applied pharmacology in dentistry, it could be said that it is a branch that is emerging with little information in this regard, so it is necessary to theoretically and scientifically evaluate a collection of chemical substances used in the field of dentistry. This research demonstrated the need to have a basic table of medications at hand, this being a specific guide for the institution and areas of dentistry, since the results found were: In the group of analgesics 87 prescribe acetaminophen, in sedatives 34 prescribe diazepan , muscle relaxants 56 prescribe methocarbamol, in antibiotics 63 they prescribe amoxicillin, in antiviral drugs 37 they prescribe acyclovir, in the group of antifungal and antibacterial drugs ketoconazole and metronidazole, both are prescribed by 14 subjects respectively. In vitamins 34 they prescribe vitamin C and 49 fluoride, in other medicines 42 they indicate toothpaste with sodium chloride and triclósan. 18 indicate benzydamine hydrochloride desensitizers and 44 indicate chlorhexidine as a mouthwash.


Subject(s)
Pharmacology , Schools, Dental , Drug Administration Routes , Drug Interactions , El Salvador , Pharmaceutical Preparations, Dental
19.
Rev. Estomat ; 1(2): 31-32, dic. 1991.
Article in Spanish | LILACS | ID: lil-569945

ABSTRACT

El odontólogo prescribe, si bien un limitado rango de fármacos, lo hace a todo el espectro de la población. La mayoría de los fármacos usados son seguros, pero en ciertas circunstancias, el odontólogo debe saber que el fármaco prescrito no es apropiado o tendrá consecuencias desastrosas. En esta revisión consideramos la paciente gestante con quien se deben tomar ciertas precauciones de prescripción. Los distintos estudios teratogénicos realizados han demostrado que muchos fármacos son capaces de causar alteraciones del desarrollo fetal. Esto indicaría por lo tanto, que sería prudente evitar todo tipo de fármacos durante la gestación, a menos que las condiciones de la paciente, como sería una infección severa, por ejemplo, excedan el riesgo de daño fetal al que pudiese llegar por el tratamiento.


Subject(s)
Pregnancy , Adrenal Cortex Hormones , Analgesics , Analgesics, Opioid , Benzodiazepines , Pregnancy , Metronidazole , Pharmaceutical Preparations, Dental , Pharmacology
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